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Genetic evidence that VKORC1L1 is not the warfarin resistant vitamin K quinone reductase present in the liver. Kaplan-Meier survival curves were determined for WT (n = 8) and Vkorc1l1−/− (c1l1; n = 6) mice, treated with either warfarin alone (150 mg/kg/day) or a combination of warfarin (warf; 150 mg/kg/day) and vitamin K1 (VK1; 15 mg/kg/day) for a maximum of 15 days (Mantel-Cox test, ** p < 0.01 and *** p < 0.001). WT: Wild-type; c1l1: Vkorc1l1; Warf: Warfarin; VK1; Vitamin K1.
