Table 1.

Role of neuropeptides in experimental models of PH.

Species	PH model	Treatment	Effect	Reference
TRPV1
Rat	Monocrotaline	Capsaicin	↓ PH, ↓RVH	Zhou and Lai, 1993; Katzman and Lai, 2000
Rat	Pulmonary banding	Capsaicin	↓ PH, ↓RVH	Xu et al., 2017
Rat	Hypoxia	Capsaicin	↑ PH, ↑RVH	Tjen et al., 1998
Rat	Perinatal hypoxia/ monocrotaline	Capsaicin	↓ PAP	Chen et al., 2012
CGRP
Rat	Post-natal hypoxia		↓ CGRP ↑ PH	Keith et al., 2000
Mouse	Hypoxia	CGRP gene transfer	↓ PH, ↓RVH	Champion et al., 2000; Bivalacqua et al., 2002
Rat	Hypoxia	CGRP	↓ PH, ↓RVH	Tjen et al., 1992
Rat	Hypoxia	CGRP receptor impaired	↑ PH	Qing and Keith, 2003
Rat	Hypoxia	CGRP infusion	↓ PH, ↓RVH	Qing and Keith, 2003
Substance P
Rat	Perinatal hypoxia/ monocrotaline		↑ Substance P	Chen et al., 2012
Rat	Monocrotaline		↑ Substance P	Zhou and Lai, 1993
Rat	Hypoxia	NK1R antagonist	↓ PAP	Chen et al., 1999
Rat	Hypoxia	NK1R activation	↑ PAP	Chen et al., 1999

CGRP, calcitonin gene-related peptide; NK1R, neurokinin 1 receptor; PH, pulmonary hypertension; RVH, right ventricular hypertrophy.