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. 2018 Aug 20;10(8):445. doi: 10.3390/v10080445

Figure 3.

Figure 3

pUS28 contributes to latent infections. Left & Middle Panels: WT infection of HPCs results in a latent infection. Left Panel: pUS28 (yellow barrels) is incorporated into the virion and is delivered upon infection [52]. Virion-delivered pUS28 aids in suppressing transcription (txn) from the MIEP [111,113], by an as of yet unidentified mechanism (dashed arrows). Middle panel: Sustained pUS28 expression throughout infection of HPCs is required for continued suppression of the MIEP, due at least in part through attenuation of MAPK and NFκB (dashed line; [56]). Right panel: When the ORF encoding US28 is deleted from the viral genome, infection of HPCs results in a lytic, rather than latent infection [52].