Table 1.

Cellular miRNAs with putative roles in herpesvirus infection.

Virus	miRNA	Targets 1	Predicted Roles	References
HSV-1	miR-101	ATP5B	Blocks DNA packaging and capsid maturation	[34]
		GRSF1	Attenuates viral replication	[33]
	miR-138	ICPO (v)	Inhibits lytic cycle gene expression	[36]
	miR-199a	ARHGAP21	Alters Golgi function disturbing viral envelopment	[48]
	miR-146a	Complement factor H	Immune evasion	[49]
		Arachidonic cascade	Alzheimer-type neurological changes	[49,50]
	miR-23a	IRF1	Innate immune evasion	[51,52]
	miR-649	MALT1	Innate and adaptive immune evasion	[53,54]
	miR-132	p300	Innate immune evasion	[55]
HCMV	miR-200 family	UL112 (v)	Inhibits viral reactivation	[39]
	miR-21-5p	Cdc25a	Inhibits viral replication	[56]
	miR-27b	EN2	Alters glioma cell morphology, neurological disorders	[57]
	miR-132	p300	Innate immune evasion	[55]
EBV	miR-200b, -429	ZEB1, ZEB2	Reactivation of lytic cycle, viral replication	[41,42]
	let-7	Dicer	Promotes latency	[43]
	miR-190	NR4A3	Inhibits lytic cycle	[58]
		TP53INP1	Enhances cell survival	[58]
	miR-424	SIAH1	Inhibits apoptosis	[59]
	miR-127	BLIMP1, XBP-1	Lymphomagenesis, blocks B-cell differentiation	[60]
KSHV	miR-320d, -498, -1258	RTA (v)	Inhibition of reactivation	[46,47]
	miR-132	p300	Innate immune evasion	[55]
	miR-21	Pdcd4, PTEN	Cell migration, invasion, angiogenesis	[61,62,63]
	miR-31	FAT4	Cell migration	[61,64]
	miR-146a	CXCR4	Cell migration	[65]
	miR-221/222 cluster	ETS1, ETS2	Cell migration	[64]
	miR-30b/c	DLL4	Angiogenesis	[66]

¹ Viral targets are indicated (v).