Figure 3.

Viral regulation of cellular signaling during latency. CMV utilizes a number of viral proteins and miRNAs during latent infection to alter the signaling environment within the cell to regulate the latent infection. This model demonstrates how each viral component either inhibits (red cross) or promotes (green arrow) cellular signaling events during a latent infection. As depicted, a number of viral factors target similar pathways demonstrating their necessity in the maintenance of and reactivation from latency.