Fig. 6.

Cued fear learning of PX-RICS/RICS–deficient mice is ameliorated by potentiating GABA_AR–mediated signaling.

(A, B) Vehicle- and CZP-injected WT and KO mice were assessed for activity (A) and averaged freezing rate (B) before tone presentation during the conditioning session.

(C, D) CZP has no significant effect on context–dependent fear learning. Freezing responses during contextual tests were analyzed based on a 300-s bin (C) or in 30-s bins over the time course of the session (D).

(E, F) Freezing responses were analyzed during the pre-CS and CS phases (E) and as a time course across these two phases (F). CZP treatment produced significant improvement in the freezing response of KO mice during the CS phase (E), particularly early in the CS phase (F).

Data are shown as the mean ± SEM. NS, not significant; **P < 0.01. Comparisons between WT (Vehicle) and KO (Vehicle) and between KO (Vehicle) and KO (CZP) are shown in (F). n = 30 (WT) and 30 (KO). Full statistical data are presented in Table S1.