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. 2018 Jul 25;34:158–164. doi: 10.1016/j.ebiom.2018.07.024

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© 2019 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — A–E - Association of serum hepcidin by ASSH quartile group with inflammatory markers: (2A and B) serum AGP and CRP; (2C) erythropoietin; (2D) Oxygen Saturation; and (2E and F) ferritin with and without inflammation. Red = low steady-state hemoglobin quartile (HbQ1); Blue = high steady-state hemoglobin quartile (HbQ4). Hepcidin cut-off demonstrated as 5.5 ng/mL. Dotted lines on the Y-axis refer to a hepcidin cut-off point at 5.5 ng/mL. Dotted lines on the X-axis are specified in the legend below.

(2A) AGP cut-off demonstrated as 120 mg/dL HbQ1 correlation coefficient 0·748 [95%CI 0·051–1·444], R 0·185, p = 0·036; HbQ4 correlation coefficient 1·064 [95%CI 0·313–1·814], R 0·246, p = 0·006)

(2B) CRP cut-off demonstrated as 5 mg/L.HbQ1 correlation coefficient 0·585 [95%CI 0·345–0·825], R 0·393, p < 0·001; HbQ4 correlation coefficient 0·449 [95%CI 0·239–0·658], R 0·359, p < 0·001)

(2C) Erythropoetin cut-off demonstrated at 9 μIU/mL. HbQ1 correlation coefficient − 0·133 [95%CI -0·527–0·261], R -0·063, p = 0·505); HbQ4 correlation coefficient − 0·291 [95%CI -0·682–0·100], R -0·136, p = 0·143

(2D) Oxygen saturation cut-off demonstrated as 97%. HbQ1 correlation coefficient − 0·064 [95%CI -0·157–0·028], r² 0·018, p = 0·170); HbQ4 correlation coefficient 0·012 [95%CI -0·155–0·178], R -0·135, p = 0·889

(2E) Ferritin cut-off demonstrated as 30 g/L. HbQ1 correlation coefficient 0·947 [95%CI 0·748–1·147], R 0·641, p < 0·001); HbQ4 correlation coefficient 1·024 [95%CI 0·784–1·263], R 0·608, p < 0·001

(2F) Red = HbQ1 with systemic inflammation; Orange = HbQ1 without systemic inflammation; Blue = HbQ4 with systemic inflammation; Black = HbQ4 without systemic inflammation. Systemic inflammation defined as AGP > 120 mg/dL and/or CRP > 5 mg/L. Without systemic inflammation - HbQ1 correlation coefficient 1·007 [95%CI 0·711–1·303], R 0·695, p < 0·001); HbQ4 correlation coefficient 1·160 [95%CI 0·868–1·453], R 0·741, <0·001 With systemic inflammation - HbQ1 correlation coefficient 0·914 [95%CI 0·629–1·200], R 0·593, p < 0·001); HbQ4 correlation coefficient 0·812 [95%CI 0·381–1·243], R 0·415, p < 0·001.