Table 4.
Incidence rates and adjusted incidence rate ratios of severe hepatotoxicity: main analysis and sensitivity analysis
| Total person-days | Number of outcome events (incidence rate per 30 person-days) | Adjusted IRR (95% CI)P-values | ||||||
|---|---|---|---|---|---|---|---|---|
| Anidulafungin | Caspofungin | Micafungin | Anidulafungin | Caspofungin | Micafungin | Anidulafungin versus caspofungin | Anidulafungin versus micafungin | |
| Main analysis | ||||||||
| Sample: all patients Outcome: severe hepatotoxicity |
26449 | 85020 | 102267 | 633 (0.72) | 993 (0.35) | 1522 (0.45) | 1.43 (1.14, 1.79)* 0.002* |
1.19 (0.92, 1.54) 0.183 |
| Sensitivity analyses | ||||||||
| Subgroup: patients with normal LFT at baseline (Grade 0) Outcome: severe hepatotoxicity |
6538 | 23703 | 33926 | 26 (0.12) | 67 (0.08) | 131 (0.12) | 0.88 (0.36, 2.14) 0.773 |
0.97 (0.46, 2.08) 0.945 |
| Subgroup: patients with normal to moderately elevated LFT at baseline (Grades 0–2) Outcome: severe hepatotoxicity |
20102 | 69188 | 84415 | 154 (0.23) | 343 (0.15) | 513 (0.18) | 1.46 (0.91, 2.37) 0.119 |
1.62 (0.95, 2.77) 0.078 |
| Sample: all patients Outcome: all-cause in-hospital death |
38246 | 104801 | 126348 | 581 (0.46) | 1188 (0.34) | 1544 (0.37) | 1.26 (1.07, 1.48)* 0.007* |
0.93 (0.77, 1.12) 0.444 |
*P-value < 0.05
Abbreviations: CI confidence interval, IRR incidence rate ratio, LFT liver function test