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. 2018 Jul 26;34:201–213. doi: 10.1016/j.ebiom.2018.07.031

Fig. 7.

Fig. 7

Effects of quercetin on MK-801-induced locomotor hyperactivity in mice with mPFC-specific genetic knockdown of γ2-GABAAR (Gabrg5) subunit. (A) Behavioral protocol. (B) Schematics of AAV vector constructs. (C) Representative images of Western blotting showing the efficacy of AAV-Gabrg2-shRNA compared with that of AAV-NC-Ctrl. (D) Sample locomotion traces of AAV-Gabrg2-shRNA infected mice to mPFC with vehicle- or quercetin (50 mg/10 ml per kg)-treatment (i.p.) and then following injection (i.p.) with saline or MK-801 (0.2 mg/10 ml per kg) in addition to a 30 min test session in the open field. (E) The total distance of AAV-NC-Ctrl-infected mice to mPFC during each 5-min interval. n = 11 for each group. ⁎⁎⁎p < .001, saline vs. MK-801; ###p < .001, vehicle vs. quercetin, two way repeated-measures ANOVA. (F) The total distance in the 30-min session of AAV-Gabrg2-shRNA-infected mice followed by saline or MK-801 injection. n = 11 for each group. ⁎p < .05, ⁎⁎p < .01, saline vs. MK-801; #p < .05, ###p < .001, vehicle vs. quercetin, unpaired Student's t-test.