Table 2.

Quantification of influenza virus-liposome contacts, modified from [11].

	HA Bridging	Pinching	Extended Interface	Hemifusion	Postfusion
Target Membrane	Not significantly deformed	Pinched and drawn to the virus envelope	Running parallel with the virus envelope. Proximal leaflets may be indistinguishable	Two proximal leaflets of lipid bilayers have joined and a diaphragm is composed of only the two remaining leaflets	Already merged with the virus envelope
HA	HAs bridge virus and liposome membrane	HAs form a fringe around the dimple	No density of HA can be observed at the contact sites	No density of HA can be observed at the contact sites	HA can adopt a variety of different conformations on the fused surface
Width of Contacts	Several to 100 nm	< 10 nm	10 – 100 nm	~100 nm	The fused complexes may grow up to 500 nm
Internal Features	Virus and liposome have not fused	Virus and liposome have not fused	Virus and liposome have not fused	No matrix layer is present and dense clumps formed by M1 and ribonucleoprotein are observed	Internal vesicles originate from multi-lamellar liposomes and dense clumps are formed by M1 and ribonucleoprotein
Example	Figure 5A	Figure 5B	Figure 5C	Figure 5D	Figure 5E