Table 1.
Kyoto Encyclopedia of Genes and Genomes pathways of genes with prognosis associated alterative splicing events (P < 0.05).
| Subtype | Term | Count | PValue | Genes |
|---|---|---|---|---|
| ESCA | hsa04144:Endocytosis | 14 | 3.59E-04 | RAB7A, CHMP3, FGFR3, USP8, ERBB3, CHMP7, PML, ARRB2, GRK6, NEDD4L, BIN1, ARAP3, CLTCL1, DNM2 |
| ESCA | hsa04120:Ubiquitin mediated proteolysis | 8 | 0.008014712 | FBXW7, HUWE1, PML, SIAH1, TCEB1, NEDD4L, ANAPC11, MID1 |
| ESCA | hsa05410:Hypertrophic cardiomyopathy (HCM) | 6 | 0.009752513 | PRKAG2, DAG1, ITGB4, SGCD, TPM2, TPM4 |
| ESCA | hsa00920:Sulfur metabolism | 3 | 0.011513671 | SUOX, ETHE1, MPST |
| hsa04512:ECM-receptor interaction | 6 | 0.015163369 | LAMA4, LAMA3, COL6A3, DAG1, ITGB4, FN1 | |
| ESCA | hsa03010:Ribosome | 7 | 0.026488508 | RPL18A, RPL32, RPLP0, RPS15, RPL37A, RPL28, RPS7 |
| ESCA | hsa04062:Chemokine signaling pathway | 8 | 0.03651303 | AKT1, PLCB3, GNAI2, ARRB2, PTK2B, BCAR1, GRK6, ELMO1 |
| ESCA | hsa05100:Bacterial invasion of epithelial cells | 5 | 0.04163531 | BCAR1, CLTCL1, ELMO1, FN1, DNM2 |
| ESCA | hsa05145:Toxoplasmosis | 6 | 0.047911017 | IRAK4, AKT1, IRAK1, LAMA4, LAMA3, GNAI2 |
| ESCA | hsa04921:Oxytocin signaling pathway | 7 | 0.049384014 | MYL6, PLCB3, GNAI2, PRKAG2, PPP3CB, CAMKK1, NFATC1 |
| STAD | hsa04520:Adherens junction | 9 | 1.13E-04 | MAP3K7, ACTG1, SORBS1, FYN, LMO7, CTNND1, CDH1, INSR, TCF7L2 |
| STAD | hsa04152:AMPK signaling pathway | 10 | 0.001052524 | MAP3K7, PRKAG2, TSC2, PPARG, STRADA, ADRA1A, TBC1D1, INSR, PIK3R1, CAMKK2 |
| STAD | hsa05410:Hypertrophic cardiomyopathy (HCM) | 8 | 0.001228388 | ACTG1, DMD, PRKAG2, ITGB4, CACNB3, TPM2, TPM1, SGCA |
| STAD | hsa04810:Regulation of actin cytoskeleton | 12 | 0.004917302 | FGFR2, ARHGEF4, ACTG1, ENAH, FGFR4, ARHGEF7, BCAR1, FGF11, ITGB4, PIP5K1A, BDKRB2, PIK3R1 |
| STAD | hsa05100:Bacterial invasion of epithelial cells | 7 | 0.005913666 | ACTG1, BCAR1, GAB1, ILK, CDH1, SHC1, PIK3R1 |
| STAD | hsa04660:T cell receptor signaling pathway | 8 | 0.005952153 | MAP3K7, PTPRC, FYN, NFATC2, GRAP2, MAP2K7, PIK3R1, NFATC1 |
| STAD | hsa04921:Oxytocin signaling pathway | 10 | 0.006097389 | MYL6, ACTG1, CAMK2G, PRKAG2, CACNB3, NFATC2, PLA2G4B, PIK3R1, CAMKK2, NFATC1 |
| STAD | hsa04380:Osteoclast differentiation | 9 | 0.006365485 | MAP3K7, IL1R1, FYN, PPARG, NFATC2, MAP2K7, IFNGR2, PIK3R1, NFATC1 |
| STAD | hsa05416:Viral myocarditis | 6 | 0.006812455 | ACTG1, FYN, DMD, CASP8, ABL2, SGCA |
| STAD | hsa05414:Dilated cardiomyopathy | 7 | 0.008444102 | ACTG1, DMD, ITGB4, CACNB3, TPM2, TPM1, SGCA |
| STAD | hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 6 | 0.016761239 | ACTG1, DMD, ITGB4, CACNB3, TCF7L2, SGCA |
| STAD | hsa04310:Wnt signaling pathway | 8 | 0.026545061 | MAP3K7, CTBP2, CCND3, CAMK2G, NFATC2, TCF7L2, NFATC1, DVL1 |
| STAD | hsa04015:Rap1 signaling pathway | 10 | 0.033404171 | FGFR2, ACTG1, FGFR4, BCAR1, EFNA3, FGF11, CTNND1, CDH1, INSR, PIK3R1 |
| STAD | hsa04012:ErbB signaling pathway | 6 | 0.036477432 | CAMK2G, GAB1, SHC1, MAP2K7, ABL2, PIK3R1 |
| STAD | hsa05166:HTLV-I infection | 11 | 0.044097891 | IL1R1, CCND3, RAN, CREM, RANBP3, ANAPC11, KAT5, NFATC2, PIK3R1, NFATC1, DVL1 |
| STAD | hsa04014:Ras signaling pathway | 10 | 0.049482855 | FGFR2, FGFR4, EFNA3, GAB1, FGF11, SHC1, ABL2, INSR, PLA2G4B, PIK3R1 |
| COAD | hsa03010:Ribosome | 8 | 0.001348748 | RPS25, RPL30, RPL34, RPL21, RPL35, RPS21, MRPL35, RPS24 |
| COAD | hsa03040:Spliceosome | 6 | 0.023574399 | NCBP2, SRSF5, PRPF3, U2AF1L4, PRPF40A, TXNL4A |
| COAD | hsa04120:Ubiquitin mediated proteolysis | 6 | 0.02638476 | UBE2D3, UBE2Z, MGRN1, TCEB1, UBE2C, MID1 |
| READ | hsa04120:Ubiquitin mediated proteolysis | 7 | 6.43E-04 | UBE3B, UBA1, TCEB1, NEDD4L, UBOX5, ITCH, CUL4B |
| READ | hsa03015:mRNA surveillance pathway | 5 | 0.00538823 | PAPOLA, SMG7, PPP2R5C, CPSF4, WDR33 |
| READ | hsa03010:Ribosome | 5 | 0.0212527 | RPS25, FAU, RPS9, RPS20, RPS3 |
| READ | hsa00230:Purine metabolism | 5 | 0.047997843 | POLR3G, ENTPD8, AK2, PDE9A, PDE4D |