Table 5.
Comparison of clinicopathological characteristics between gastric cancer patients with and without metabolic syndrome by CDS definition in males and females.
| Features | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MetS (n*, %) | BMI (n, %) | TG (n*, %) | HDL-C (n, %) | Hypertension (n*, %) | Diabetes (n*, %) | MetS (n*, %) | BMI (n*, %) | TG (n*, %) | HDL-C (n*, %) | Hypertension (n*, %) | Diabetes (n*, %) | |
| LOCATION | ||||||||||||
| Proximal | 54 (19.1) | 95 (33.7) | 42 (14.9) | 40 (15.2) | 80 (28.4) | 76 (27.0) | 2 (3.8) | 19 (36.5) | 6 (11.5) | 10 (19.2) | 8 (15.4) | 10 (19.2) |
| Distal | 78 (24.8) | 82 (26.1) | 68 (21.7) | 48 (15.4) | 78 (24.8) | 66 (21.0) | 20 (12.5) | 46 (28.9) | 36 (22.5) | 36 (22.5) | 46 (28.8) | 36 (22.5) |
| x2 | 2.791 | 4.081 | 4.514 | 0.143 | 0.949 | 2.880 | 3.160 | 1.120 | 2.968 | 0.247 | 3.693 | 0.247 |
| p | 0.114 | 0.048 | 0.034 | 0.730 | 0.353 | 0.102 | 0.113 | 0.303 | 0.109 | 0.691 | 0.067 | 0.701 |
| BORRMANN TYPE | ||||||||||||
| I | 30 (31.1) | 39 (27.8) | 10 (8.2) | 12 (9.8) | 44 (36.1) | 38 (31.1) | 4 (10.0) | 17 (42.5) | 10 (25.0) | 12 (30.0) | 8 (20.0) | 6 (11.5) |
| II | 36 (21.2) | 55 (32.4) | 30 (17.6) | 26 (15.3) | 38 (22.4) | 38 (21.4) | 6 (11.1) | 15 (27.8) | 14 (25.9) | 12 (22.2) | 12 (22.2) | 16 (29.6) |
| III | 60 (22.0) | 75 (26.2) | 62 (21.7) | 46 (16.1) | 70 (24.5) | 60 (22.0) | 12 (11.8) | 31 (30.4) | 14 (13.7) | 22 (21.6) | 32 (31.4) | 20 (19.6) |
| IV | 6 (33.3) | 2 (11.1) | 8 (44.4) | 4 (22.2) | 6 (33.3) | 6 (33.3) | 0 (0.0) | 6 (37.5) | 4 (25.0) | 0 (0.0) | 2 (12.5) | 4 (25.0) |
| x2 | 2.048 | 5.054 | 18.657 | 3.584 | 8.264 | 5.980 | 1.051 | 2.759 | 4.598 | 6.066 | 4.220 | 3.421 |
| p | 0.632 | 0.168 | < 0.001 | 0.310 | 0.041 | 0.113 | 0.789 | 0.445 | 0.204 | 0.108 | 0.469 | 0.331 |
| HISTOLOGICAL GRADE | ||||||||||||
| Well- | 18 (11.8) | 51 (33.6) | 20 (13.2) | 6 (3.9) | 42 (27.6) | 40 (26.3) | 2 (6.7) | 12 (40.0) | 6 (20.0) | 4 (13.3) | 3 (20.0) | 4 (13.3) |
| Poor- | 114 (25.7) | 120 (27.0) | 90 (20.3) | 82 (18.5) | 116 (26.1) | 102 (23.0) | 20 (11.0) | 59 (32.4) | 36 (19.8) | 42 (21.0) | 24 (26.4) | 42 (23.1) |
| x2 | 12.568 | 2.357 | 3.806 | 18.972 | 0.132 | 0.697 | 0.517 | 0.665 | 0.000 | 1.439 | 0.551 | 1.439 |
| p | < 0.001 | 0.146 | 0.053 | < 0.001 | 0.750 | 0.404 | 0.747 | 0.412 | 1.000 | 0.339 | 0.651 | 0.339 |
| T STAGE | ||||||||||||
| T1 | 10 (10.6) | 30 (31.9) | 28 (29.8) | 6 (6.4) | 16 (17.0) | 18 (19.1) | 1 (3.3) | 16 (44.4) | 4 (11.1) | 8 (22.2) | 6 (16.7) | 10 (27.8) |
| T2 | 18 (19.6) | 28 (29.8) | 16 (17.0) | 10 (10.6) | 22 (23.4) | 22 (23.4) | 3 (6.0) | 10 (20.0) | 8 (16.0) | 4 (8.0) | 14 (28.0) | 10 (20.0) |
| T3 | 22 (26.5) | 21 (24.4) | 18 (20.9) | 24 (27.9) | 20 (23.3) | 20 (23.3) | 5 (31.3) | 7 (43.8) | 0 (0.0) | 2 (12.5) | 4 (25.0) | 0 (0.0) |
| T4 | 82 (25.1) | 95 (29.5) | 48 (14.0) | 48 (14.9) | 100 (31.1) | 82 (25.5) | 13 (11.8) | 33 (30.0) | 30 (27.3) | 32 (29.0) | 30 (27.3) | 26 (23.6) |
| x2 | 10.356 | 1.316 | 11.193 | 18.327 | 8.693 | 1.635 | 11.006 | 7.120 | 9.980 | 9.863 | 1.808 | 5.545 |
| p | 0.016 | 0.725 | 0.011 | < 0.001 | 0.034 | 0.652 | 0.012 | 0.068 | 0.019 | 0.020 | 0.909 | 0.136 |
| N STAGE | ||||||||||||
| N0 | 46 (16.8) | 83 (30.3) | 60 (21.9) | 38 (13.9) | 64 (23.4) | 54 (19.7) | 6 (5.2) | 21 (18.1) | 20 (17.2) | 22 (19.0) | 28 (24.1) | 24 (20.7) |
| N1 | 34 (31.5) | 29 (26.9) | 20 (18.5) | 18 (16.7) | 32 (29.6) | 28 (25.9) | 4 (12.5) | 11 (34.4) | 8 (25.0) | 8 (25.0) | 8 (25.0) | 4 (12.5) |
| N2 | 32 (25.0) | 40 (31.2) | 18 (14.1) | 20 (15.6) | 36 (28.1) | 38 (29.7) | 4 (15.4) | 10 (38.5) | 2 (7.7) | 4 (15.4) | 8 (30.8) | 6 (23.1) |
| N3 | 20 (23.3) | 25 (29.1) | 12 (14.0) | 22 (14.0) | 26 (30.2) | 22 (25.6) | 8 (21.1) | 11 (28.9) | 12 (31.6) | 12 (31.6) | 10 (26.3) | 12 (31.6) |
| x2 | 10.686 | 0.629 | 4.857 | 0.606 | 2.720 | 5.392 | 8.891 | 7.271 | 6.741 | 3.509 | 0.511 | 3.876 |
| p | 0.014 | 0.890 | 0.175 | 0.895 | 0.437 | 0.145 | 0.031 | 0.064 | 0.081 | 0.320 | 0.916 | 0.275 |
| TNM STAGE | ||||||||||||
| I | 20 (12.0) | 41 (24.6) | 42 (25.3) | 8 (4.8) | 36 (21.7) | 36 (21.7) | 2 (2.9) | 29 (41.4) | 10 (14.3) | 12 (17.1) | 16 (22.9) | 14 (20.0) |
| II | 40 (26.0) | 36 (23.4) | 28 (18.2) | 44 (28.6) | 34 (22.2) | 30 (19.5) | 6 (9.1) | 16 (24.2) | 14 (21.2) | 12 (18.2) | 16 (24.2) | 16 (24.0) |
| III + IV | 72 (26.1) | 91 (33.0) | 40 (14.5) | 36 (13.0) | 88 (28.9) | 76 (27.5) | 14 (18.4) | 22 (28.9) | 18 (23.7) | 22 (28.9) | 22 (28.9) | 16 (21.1) |
| x2 | 13.611 | 5.977 | 8.057 | 37.023 | 7.626 | 4.114 | 9.661 | 5.357 | 2.144 | 3.686 | 0.788 | 0.389 |
| p | 0.001 | 0.049 | 0.018 | < 0.001 | 0.022 | 0.128 | 0.008 | 0.069 | 0.232 | 0.158 | 0.674 | 0.832 |
*
n was positive patients number.
MetS, metabolic syndrome were identified by CDS; BMI ≥25.0 kg/m2; TG ≥1.70 mmol/L; HDL-C < 0.9 mmol/L for male, < 1.09 mmol/L for female; Hypertension: systolic BP ≥140, diastolic BP ≥90 mmHg or hypertension history; Diabetes ≥ 6.1 mmol/L or diabetes history.