Table 5.
Factors associated with chronic (moderate/severe) and acute (moderate/severe) gastritis and intestinal metaplasia among Alaska native adults positive for H. pylori (Hp) by histological assessment; 1998–2005.
| Factor | Level (n) | Acute gastritis (mod/sev) |
Chronic gastritis (mod/sev) |
Intestinal metaplasia |
|||
|---|---|---|---|---|---|---|---|
| % with (n) | p-value | % with (n) | p-value | % with (n) | p-value | ||
| Age ≥50 Years | Yes (n = 106) | 43% (46) | 0.43 | 76% (81) | 0.03 d | 22% (23) | 0.0007 d |
| No (n = 153) | 48% (74) | 87% (133) | 7% (11) | ||||
| Sex | F (n = 153) | 44% (67) | 0.32 | 84% (129) | 0.39 | 10% (16) | 0.13 |
| M (n = 106) | 50% (53) | 80% (85) | 17% (18) | ||||
| Study arm | Urban (n = 177) | 47% (84) | 0.59 | 81% (143) | 0.24 | 14% (24) | 0.76 |
| Rural (n = 82) | 44% (36) | 87% (71) | 12% (10) | ||||
| Obese (BMI ≥30 | Yes (n = 82) | 49% (40) | 0.57 | 85% (70) | 0.47 | 11% (9) | 0.47 |
| No (n = 147) | 45% (66) | 82% (120) | 14% (21) | ||||
| Alcohol use (any) | Yes (n = 98) | 50% (49) | 0.38 | 86% (84) | 0.35 | 13% (13) | 0.86 |
| No (n = 160) | 44% (71) | 81% (130) | 13% (20) | ||||
| Current smoker a | Yes (n = 62) | 39% (24) | 0.17 | 74% (46) | 0.05 d | 15% (9) | 0.71 |
| No (n = 197) | 49% (96) | 85% (168) | 13% (25) | ||||
| Concentration of HP | Focal (n = 45) | 18% (8) | < 0.0001 d | 53% (24) | <0.0001 d | 16% (7) | 0.85 |
| Moderate (n = 123) | 46% (57) | 88% (108) | 12% (15) | ||||
| Numerous (n = 91) | 60% (55) | 90% (82) | 13% (12) | ||||
| High anti-HP IgG c | Yes (n = 45) | 58% (26) | 0.07 | 93% (42) | 0.01 | 4% (2) | 0.03 |
| No (n = 185) | 43% (79) | 79% (146) | 15% (28) | ||||
| Intact CAGe | Yes (n = 120) | 62% (74) | 0.0002 d | 88% (105) | 0.79 | 16% (19) | 0.09 d |
| No (n = 97) | 36% (35) | 89% (86) | 8% (8) | ||||
a ≥10 cigarettes/day.
b ≥20 delta over baseline.
c OD ≥ 1.5.
d Significant in multivariate model.
ecagPAI.