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. 2018 Aug 23;9:470. doi: 10.3389/fendo.2018.00470

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Copyright © 2018 Hiramitsu, Ishikawa, Lee, Khan, Crumbley, Khwaja, Zamanian, Asghari, Sen, Zhang, Hawse, Minna and Umetani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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27HC promotes H1395 lung cancer cell proliferation. (A) Cell proliferation assay. Vehicle control, E₂ (10 nM), or 27HC (1 μM) were treated for 24 h (n = 4). (B) Dose response of 27HC in H1395 cell proliferation (n = 4). (C) H1395 cell proliferation in the presence of oxysterols for 24 h (n = 4). 4βHC, 4β-hydroxycholesterol; 7KC, 7keto-cholesterol; 22RHC, 22(R)-hydroxycholesterol; 24SHC, 24(S)-hydroxycholesterol; 25HC, 25-hydroxycholesterol; αEPOX, cholesterol 5α,6α-epoxide; βEPOX, cholesterol 5β,6β-epoxide; TRI, cholestane-3β,5α,6β-triol; 6KC, 5α-hydroxy-6-ketocholesterol; and Chol, cholesterol at 0.1 μM (open bars) and 1 μM (closed bars). ^*p < 0.05 vs. vehicle control.