Table 1.

Search strategies.

Electronic bases	Search strategies	Files retrieved
MEDLINE (PubMed)	((((((((((((((((((((((((((‘Diabetes Mellitus, Type 1’ [Mesh]) OR ‘Diabetic Ketoacidosis’ [Mesh]) OR Insulin-Dependent Diabetes Mellitus [Text Word]) OR Diabetes Mellitus, Insulin-Dependent, 1 [Text Word]) OR Diabetes Mellitus Juvenile-Onset [Text Word]) OR Juvenile-Onset Diabetes Mellitus [Text Word]) OR Diabetes Mellitus, Sudden Onset [Text Word])) OR IDDM [Text Word])) OR Juvenile-Onset Diabetes [Text Word])) OR Diabetes Mellitus Brittle [Text Word])) OR Diabetes Mellitus Ketosis-Prone [Text Word])) OR Diabetes, Autoimmune [Text Word])) Or Autoimmune Diabetes [Text Word])) OR Ketoacidoses, Diabetic [Text Word])) OR Acidosis, Diabetic [Text Word])) AND ((((((((((((, Insulin Detemir [MeSH Terms]) OR Basal Insulin Detemir [Text Word])) OR Detemir Basal Insulin, [Text Word])) OR Insulin Detemir, Basal [Text Word])) OR NN304 [Text Word])) OR NN-304 [Text Word])) OR Levemir [Text Word])) AND ((((((((Glargine, Insulin [MeSH Terms]) OR Glargine [Text Word])) OR HOE 901 [Text Word])) OR 901, HOE [Text Word])) OR Lantus [Text Word]))	117
EMBASE	#1 ‘diabetic ketoacidosis/exp’ OR ‘diabetic acidosis’ OR ‘diabetes’ OR ‘acidosis ketoacidosis diabetes’ OR ‘diabetes’ OR ‘ketosis’ OR ‘diabetic acidosis diabetic ketosis’ OR ‘insulin dependent diabetes mellitus/exp’ OR ‘brittle’ OR ‘brittle diabetes diabetes mellitus’ OR ‘diabetes mellitus type 1’ OR ‘type i diabetes mellitus’ OR ‘diabetes mellitus, insulin-dependent diabetes mellitus’ OR ‘type 1’ OR ‘diabetes, type i diabetes mellitus’ OR ‘brittle’ OR ‘diabetes, insulin dependent diabetes mellitus’ OR ‘juvenile onset’ OR ‘diabetes type 1 diabetes type’ OR ‘i’ OR ‘diabetes, juvenile’ OR ‘dm’ OR ‘1 early onset diabetes mellitus’ OR ‘iddm insulin dependent diabetes’ OR ‘juvenile diabetes’ OR ‘juvenile diabetes mellitus’ OR ‘juvenile onset diabetes’ OR ‘juvenile onset diabetes mellitus’ OR ‘ketoacidotic diabetes’ OR ‘labile diabetes mellitus’ OR ‘type 1’ OR ‘type 1 diabetes diabetes mellitus’ OR ‘type i diabetes’ OR ‘type i diabetes mellitus’, #2 ‘/exp’ OR ‘insulin isophane nph insulin glargine’, #3 ‘/exp’ OR ‘abasaglar’ OR ‘abasria’ OR ‘basaglar’ OR ‘insulin glargine’ OR ‘hoe 901’ OR ‘hoe901’ OR ‘insulin glargine recombinant’ OR ‘insulin [a21 glycine b31 b32 arginine arginine]’ OR ‘lantus’ OR ‘lantussolostar’ OR ‘ly’ OR ‘2963016’ OR ‘ly2963016’ OR ‘optisulin optisulin depot’ OR ‘optisulin long’ OR ‘toujeo’, #4 ‘/exp’ OR ‘detemir insulin levemir’ and cohort analysis ‘/exp’ OR ‘controlled clinical trial’ ‘/exp’ OR ‘/exp #1’ AND #2 AND #3 AND #4	472
Cochrane Library	#1 MeSH descriptor: [Diabetes Mellitus, Type 1] explodes all trees #2 MeSH descriptor: [Diabetic Ketoacidosis] explodes all trees #3 Diabetes Mellitus, Insulin-Dependent (Word variations have been searched), Insulin Dependent Diabetes Mellitus #4 (Word variations have been searched) #5 Diabetes Mellitus, Insulin Dependent Juvenile Onset $ #6–#7 Diabetes Mellitus Type 1 Diabetes #8 Diabetes Mellitus, Type I Diabetes, Autoimmune #9 #10 {or #1–#9} #11 MeSH descriptor: [Insulin Glargine] explodes all trees glargine Lantus #13 #12 #14 {#11–#13 or} #15 MeSH descriptor: [Insulin Detemir] explodes all trees #16, Insulin Detemir (Word variations have been searched) Insulin Detemir Basal #17 (Word variations have been searched) #18 Basal Insulin Detemir,: ti, ab, kw (Word variations have been searched) Levemir #19 #20 {or #15–#19} #21 #14 #20 #22 #10 and #21 and #23 MeSH descriptor: [Cohort Studies] explodes all trees $ cohort epidemiologic methods #25 #24 #26 controlled clinical trial #27 {or #23-#26} #28 #22 and #27	109
LILACS	((((((((‘DIABETIC KETOACIDOSIS’) or ‘DIABETES MELLITUS TYPE 1’) or ‘INSULIN-DEPENDENT’ DIABETES MELLITUS) or ‘AUTOIMMUNE DIABETES’) or ‘DIABETES MELLITUS’) or ‘KETOACIDOSIS DIABETICA’) or ‘DIABETES’) or ‘IDDM’) or ‘INSULIN-DEPENDENT DIABETES MELLITUS’ [Words] an d (((‘GLARGINE’) or ‘LANTUS’) or ‘LANTUS SOLOSTAR’) or ‘GLARGINE’ [Words] and ((‘DETEMIR’) or ‘LEVEMIR’) or ‘INSULIN DETEMIR’ [Words]	7