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. 2018 Aug 3;49(9):2182–2190. doi: 10.1161/STROKEAHA.118.020124

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© 2018 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Loss of RGS5 (regulator of G-protein signaling 5) leads to increased pericyte numbers after stroke. A, Schematic representation of a coronal brain section showing location of infarct core. Representative images showing GFP⁺ (green fluorescent protein) pericytes in the infarct core in heterozygous (HET; top) and knockout (KO; bottom) mice; scale bar, 20 μm. Platelet-derived growth factor receptor (PDGFR) β⁺ pericytes in the infarct core of wild type (WT; top), HET (middle), and KO (bottom) mice; scale bar, 20 μm. B, Higher number of GFP⁺ pericytes in infarct core in KO mice compared with HET (n=7, **P<0.01, Student t test). C, Quantification of PDGFRβ⁺ pericytes in the infarct area in KO (n=5), HET (n=4), and WT (n=5) mice (****P<0.0001; ***P<0.001 1-way ANOVA, Tukey post hoc test). Data are expressed as cell numbers per mm²; mean±SD. Ic indicates ischemic core.