Figure 5.

Maintained blood-brain barrier integrity in RGS5 (regulator of G-protein signaling 5)-knockout (KO) mice in stroke. A, Distribution of 10 kDa dextran-tracer (cyan) in the infarct area in wild type (WT) and KO mice. Dextran is mainly intravascularly distributed in CD31-positive blood vessels (red) in KO mice, whereas it leaks more into the brain parenchyma in WT mice. Right, Higher magnification of framed areas in WT and KO mice; scale bars, 50 μm (left), 20 μm (middle), and 10 μm (right). B, Quantification of extravasation of the 10 kDa dextran of KO mice vs WT after stroke; mean±SD (n=3 ***P<0.001, Student t test).