. 2018 May 11;7(5):859–873. doi: 10.1039/c8tx00045j

Table 4. Incidence of exposure-related histopathologic lesions in male rats in the control and treatment groups.

Tissue and lesion	Control	DEHP
Tissue and lesion	Control	100 mg kg^–1 per day	200 mg kg^–1 per day	400 mg kg^–1 per day
Testes
Combined tubules	0/6	1/6	1/6	5/6^a
Atrophic tubules	0/6	2/6	3/6	5/6^a
Pycnotic nucleus	0/6	1/6	5/6^a	6/6^a
Congestion	0/6	6/6^a	6/6^a	6/6^a
Vacuolization of Sertoli cell	0/6	3/6	6/6^a	6/6^a
Cells in the lumen	0/6	2/6	5/6^a	6/6^a
Tubules without sperm	0/6	3/6	6/6^a	5/6^a
Degeneration of tubules	0/6	6/6^a	6/6^a	6/6^a
Epididymis
Atrophic tubules	0/6	2/6	1/6	2/6
Spermatogenic cell	0/6	0/6	0/6	1/6
Tight lumens of tubules	0/6	6/6^a	6/6^a	5/6^a
Tubules without sperm	0/6	2/6	6/6^a	6/6^a
Less sperm in the lumen	0/6	6/6^a	6/6^a	6/6^a
Prostate gland
Mononuclear cell infiltration	0/6	3/6	2/6	6/6^a
Atrophic tubules	0/6	6/6^a	6/6^a	6/6^a
Prostatic intraepithelial neoplasia	0/6	5/6^a	6/6^a	6/6^a
Seminal vesicle
Decrement of secretion	0/6	6/6^a	6/6^a	6/6^a
Cells in the lumen	0/6	5/6^a	5/6^a	3/6