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. Author manuscript; available in PMC: 2018 Aug 30.
Published in final edited form as: Endocrinology. 2008 May 15;149(9):4605–4614. doi: 10.1210/en.2008-0321

Figure 2. Kisspeptin excites GnRH neurons via an intrinsic mechanism independent upon external neural transmission.

Figure 2

A, representative voltage trace showing kisspeptin-induced depolarization and firing was not affected by antide (100 nM) administered during the kisspeptin activation. B, representative voltage trace showing kisspeptin-induced depolarization was not affected by TTX (0.5 μM administered during the kisspeptin activation. C, representative voltage trace showing kynurenic acid (1 mM) and picrotoxin (0.1 mM) (Ka+Pt) blocking synaptic events but having no effect on the kisspeptin-induced depolarization.