Table 1. P values and odds ratios for associations with MLCKP1 polymorphisms in African and European American colorectal cancer.
| SNP | BP | MA | F_A | F_U | P_allele | OR (95% CI) | P_dom | P_rec | P_add | OR_add (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| African Americans | ||||||||||
| rs10490780 | 75325508 | G | 0.140 | 0.148 | 0.687 | 0.94 (0.69,1.28) |
0.761 | 0.694 | 0.698 | 0.94 (0.70,1.28) |
| rs9824516 | 75326959 | A | 0.132 | 0.124 | 0.657 | 1.08 (0.77,1.51) |
0.575 | 0.845 | 0.663 | 1.08 (0.77,1.50) |
| rs7638312 | 75327606 | C | 0.061 | 0.057 | 0.775 | 1.07 (0.67,1.71) |
NA | NA | 0.780 | 1.07 (0.68,1.69) |
| rs6796799 | 75328126 | A | 0.273 | 0.270 | 0.907 | 1.02 (0.79,1.30) |
0.919 | 0.636 | 0.907 | 1.02 (0.79,1.30) |
| rs4677497 | 75328974 | G | 0.155 | 0.164 | 0.666 | 0.93 (0.69,1.27) |
0.581 | 0.853 | 0.665 | 0.93 (0.69,1.27) |
| rs12490683 | 75329934 | A | 0.238 | 0.186 | 0.023 | 1.37 (1.04,1.80) |
0.208 | 0.002 | 0.029 | 1.35 (1.03,1.76) |
| rs12497343 | 75330074 | G | 0.264 | 0.216 | 0.047 | 1.30 (1.00,1.69) |
0.159 | 0.018 | 0.041 | 1.33 (1.01,1.74) |
| rs6801219 | 75332618 | G | 0.102 | 0.121 | 0.293 | 0.83 (0.59,1.18) |
0.282 | 0.802 | 0.312 | 0.84 (0.60,1,12) |
| rs2091870 | 75333283 | G | 0.338 | 0.345 | 0.781 | 0.97 (0.77,1.22) |
0.509 | 0.665 | 0.784 | 0.97 (0.77,1.22) |
| rs4552385 | 75336163 | C | 0.466 | 0.457 | 0.747 | 1.04 (0.83,1.29) |
0.711 | 0.342 | 0.753 | 1.04 (0.83,1.28) |
| rs4677503 | 75338306 | A | 0.323 | 0.311 | 0.466 | 1.09 (0.86,1.39) |
0.357 | 0.946 | 0.482 | 1.09 (0.86,1.36) |
| European Americans | ||||||||||
| rs6796799 | 75328126 | A | 0.134 | 0.124 | 0.623 | 1.10 (0.75,1.61) |
NA | NA | 0.62 | 1.10 (0.75,1.61) |
| rs4677497 | 75328974 | G | 0.118 | 0.112 | 0.795 | 1.06 (0.70,1.59) |
NA | NA | 0.80 | 1.05 (0.71,1.58) |
| rs12490683 | 75329934 | G | 0.381 | 0.364 | 0.603 | 1.07 (0.83,1.39) |
0.831 | 0.432 | 0.58 | 1.08 (0.82,1.41) |
| rs12497343 | 75330074 | C | 0.393 | 0.382 | 0.714 | 1.05 (0.81,1.36) |
0.609 | 0.964 | 0.69 | 1.06 (0.80,1.39) |
| rs2091870 | 75333283 | A | 0.368 | 0.339 | 0.374 | 1.13 (0.87,1.48) |
0.728 | 0.165 | 0.35 | 1.14 (0.87,1.50) |
| rs4552385 | 75336163 | T | 0.305 | 0.300 | 0.882 | 1.02 (0.77,1.35) |
0.724 | 0.304 | 0.88 | 1.02 (0.77,1.37) |
| rs4677503 | 75338306 | G | 0.333 | 0.311 | 0.470 | 1.11 (0.84,1.45) |
0.963 | 0.109 | 0.47 | 1.10 (0.84,1.44) |
P_allele is the p value obtained in the chi square test of allele frequency, and it is associated with odds ratio (OR) and 95% confidence interval (CI) in the adjacent column; P_dom is the value obtained assuming a dominant genetic model; P_rec is the value obtained assuming a recessive genetic model. P_add is the unadjusted p value obtained from a logistic regression assuming a log-additive genetic model, and it is associated with OR and 95% CI in the adjacent column. NA indicates that the frequency of one of the genotypes was too low to perform the test of the model. For the nominally significant SNPs, rs12490683 and rs12497343, the lowest p values obtained in the analysis are in bold. There are four fewer SNPs displayed in the European American part of the table because the minor allele frequency of the excluded SNPs was less than 0.05.
BP, base pair position on chromosome 3, GRCh38; F_A, frequency of minor allele in colorectal cancer cases; F_U, frequency of minor allele in controls; MA, minor allele; SNP, single nucleotide polymorphism.