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. 2018 Jul 16;210(1):137–153. doi: 10.1534/genetics.118.301261

Figure 8.

Figure 8

Schematic representation of the GCK signaling network in animals and fungi. The animal model is generated based on the data obtained from the H. sapiens and D. melanogaster studies (referenced in the Introduction). The S. macrospora model is based on the data from Sc. pombe (Singh et al. 2011) and N. crassa (Heilig et al. 2013, 2014), as well as previous data from S. macrospora (Frey et al. 2015) and this study. STRIPAK corresponds to a striatin-interacting phosphatase and kinase complex. GCKs are represented as yellow ovals. NDR kinases are represented as green rectangles. Corresponding pathways are highlighted in green/pink. Solid black arrows indicate canonical kinase activation; solid gray arrows indicate optional bypass kinase activation; and dashed blunt-ended black lines indicate negative regulation. GCK, germinal center kinase; MOR, morphogenesis Orb6; NDR, nuclear Dbf2-related; SIN, septation initiation network; STRIPAK, striatin-interacting phosphatases and kinases.