Table 3. Protein concentrations across tertiles of beta-cell function measures.
| Beta-cell function/HOMA-IR related proteins | T1 (4.57 ± 2.07 pmol/mmol) | T2 (10.27 ± 1.70 pmol/mmol) | T3 (23.67 ± 8.16 pmol/mmol) | P |
| Beta-Endorphin | 488.8 ± 78.99 | 502.3 ± 49.68 | 554.4 ± 140.92 | 0.021 |
| Cripto-1 growth factor | 605.8 ± 58.07 | 593.3 ± 42.91 | 571.0 ± 40.91 | 0.015 |
| IL-17F | 888.8 ± 92.82 | 850.0 ± 64.94 | 834.8 ± 90.68 | 0.029 |
| IL-22 | 470.7 ± 55.60 | 459.8 ± 51.09 | 439.9 ± 46.80 | 0.055 |
| JAM-B | 2857.4 ± 315.83 | 2765.3 ± 337.85 | 2606.3 ± 285.67 | 0.007 |
| Galectin-2 | 950.8 ± 122.81 | 986.5 ± 106.39 | 1064.1 ± 154.43 | 0.002 |
| ADAMS13 | 3488.5 ± 634.12 | 3724.8 ± 803.32 | 3976.6 ± 931.83 | 0.051 |
| WFIKKN2 | 4470.5 ± 846.64 | 4898.6 ± 1036.92 | 5120.2 ± 1095.08 | 0.030 |
| Carbonic Anhydrase X | 672.6 ± 67.27 | 653.2 ± 49.11 | 648.2 ± 45.63 | 0.091 |
| MASP-3 | 5498.5 ± 778.32 | 5190.6 ± 715.11 | 4995.6 ± 840.04 | 0.034 |
| PLA2G2E | 360.4 ± 30.03 | 375.9 ± 35.09 | 388.3 ± 47.64 | 0.015 |
| EphB4 | 20856.3 ± 2139.79 | 20002.2 ± 2374.49 | 19132.2 ± 3287.01 | 0.034 |
| LGMN | 9492.1 ± 986.24 | 8905.2 ± 952.61 | 8626.7 ± 1292.85 | 0.006 |
| MED-1 | 541.1 ± 38.16 | 555.8 ± 55.16 | 583.8 ± 76.79 | 0.014 |
| Mesothelin | 559.5 ± 83.80 | 599.2 ± 151.19 | 697.4 ± 361.64 | 0.055 |
| Calcineurin | 496.1 ± 95.12 | 556.3 ± 104.01 | 572.0 ± 133.11 | 0.017 |
| D-dimer | 2249.7 ± 386.28 | 2248.5 ± 391.11 | 2483.4 ± 530.12 | 0.053 |
| Peroxiredoxin-5 | 573.9 ± 51.50 | 598.0 ± 66.48 | 629.8 ± 145.52 | 0.072 |
| CRTAM | 714.3 ± 75.25 | 747.0 ± 82.22 | 773.6 ± 167.40 | 0.142 |
| STK17B | 10299.7 ± 1222.92 | 9811.8 ± 1190.98 | 9412.9 ± 1541.83 | 0.028 |
| LSAMP | 1475.2 ± 230.80 | 1523.0 ± 182.98 | 1637.0 ± 279.46 | 0.018 |
| Stromelysin-2 | 698.2 ± 134.68 | 664.6 ± 63.11 | 729.4 ± 94.73 | 0.038 |
| Disposition Index related proteins | T1 (1.08 ± 0.45 pmol/mmol) | T2 (2.30 ± 0.39 pmol/mmol) | T3 (5.33 ± 1.80 pmol/mmol) | P |
| Beta-Endorphin | 488.0 ± 78.17 | 499.0 ± 51.31 | 558.7 ± 138.90 | 0.009 |
| IGFBP-3 | 1055.6 ± 234.27 | 1133.9 ± 159.66 | 1192.6 ± 212.11 | 0.028 |
| Cripto-1 growth factor | 605.9 ± 56.36 | 593.7 ± 43.10 | 570.5 ± 42.83 | 0.013 |
| JAM-B | 2826.3 ± 313.07 | 2783.8 ± 350.27 | 2617.9 ± 287.18 | 0.025 |
| Galectin 2 | 950.1 ± 124.59 | 991.8 ± 100.17 | 1059.2 ± 159.46 | 0.004 |
| Cathepsin B | 2145.2 ± 232.24 | 2148.3 ± 274.98 | 2219.3 ± 346.06 | 0.499 |
| Carbonic Anhydrase X | 673.2 ± 67.91 | 651.6 ± 50.66 | 649.3 ± 42.05 | 0.171 |
| Stromelysin-2 | 703.4 ± 133.67 | 655.2 ± 58.50 | 734.1 ± 93.25 | 0.007 |
| Peroxiredoxin-5 | 571.7 ± 50.69 | 600.5 ± 66.86 | 629.3 ± 145.30 | 0.062 |
| CRTAM | 718.9 ± 73.34 | 742.0 ± 81.96 | 775.1 ± 168.90 | 0.167 |
| MASP-3 | 5468.0 ± 768.34 | 5183.3 ± 760.26 | 5033.6 ± 827.38 | 0.079 |
| EphB4 | 20733.6 ± 2014.20 | 20023.6 ± 2565.95 | 19232.8 ± 3217.17 | 0.078 |
| LGMN | 9454.4 ± 995.39 | 8932.0 ± 1039.30 | 8636.8 ± 1234.69 | 0.011 |
| STK17B | 10264.8 ± 1203.18 | 9800.0 ± 1264.52 | 9459.9 ± 1519.56 | 0.053 |
| Calcineurin | 490.4 ± 91.73 | 547.6 ± 99.45 | 586.7 ± 133.39 | 0.002 |
| D-dimer | 2234.7 ± 385.76 | 2255.4 ± 397.06 | 2491.9 ± 521.38 | 0.037 |
| Mesothelin | 558.7 ± 82.67 | 607.8 ± 152.97 | 690.4 ± 363.48 | 0.076 |
Protein concentrations (relative fluorescence units) displayed as mean ± standard deviations across tertiles (T) of beta-cell functions measures. P-values obtained from one way ANOVA, overall P-value displayed.