Table 4. Pathways significantly related to beta-cell function measures.
| WikiPathway ID | Pathway | Positive | Measured by SOMAscan assay | Z Score | P | % of total gene products measured in pathway | Significant proteins |
|---|---|---|---|---|---|---|---|
| Beta-cell function/ HOMA-IR | |||||||
| WP558 | Complement and Coagulation Cascades | 8 | 40 | 2.57 | 0.02 | 64.4 | TFPI, a1-antitrypsin, kininogen HMW, C7, MASP3, C1s, coagulation factor IX/ coagulation factor IXab, C3a |
| WP545 | Complement Activation | 5 | 17 | 3.03 | 0.03 | 77.3 | C7, C3a, C1s, Masp3, Properdin |
| WP2064 | Neural Crest Differentiation | 5 | 18 | 2.88 | 0.01 | 17.8 | Cadherin 2, Cadherin 6, FGFR2, MIA, HDAC8 |
| WP2858 | Ectoderm Differentiation | 4 | 17 | 2.17 | 0.03 | 11.3 | Cadherin 6, FGFR2, MCP1, GIB |
| WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR | 3 | 3 | 5.59 | <0.001 | 6.3 | HDAC8, Calcineurin, Calcineurin Ba |
| Disposition Index | |||||||
| WP558 | Complement and Coagulation Cascades | 8 | 40 | 2.98 | 0.01 | 64.4 | TFPI, a1-antitrypsin, kininogen HMW, C7, MASP3, C1s, coagulation factor IX/ coagulation factor IXab, C3a |
| WP545 | Complement Activation | 4 | 17 | 2.47 | 0.03 | 77.3 | C7, C3a, C1s, MASP3 |
Pathways obtained from pathway statistics using PathVisio software, using the curated WikiPathways directory. Sorted by number of differentially expressed proteins (positive) in pathway (measured by SOMAscan assay). P-value is permuted, p < 0.05 is considered significant. Percentage of total gene products refers to % coverage of pathway by SOMAscan assay.