Fig 8. Model of basolateral actin redistribution enabling isotropic retinal growth.

During growth of the wild-type zebrafish retinal PSE, a basolateral actin accumulation disappears tissue-wide between 36 hpf and 42 hpf, coinciding with an increase in cell height. In the hdac1−/− retinal PSE, the basolateral actin does not redistribute, and cells do not elongate past 55 μm. Such cytoskeletal redistribution mechanically enables cell elongation by changing the tension balance within the cells and, consecutively, results in maintenance of retinal tissue shape during proliferative growth. hdac1, histone-deacetylase 1; hpf, hours post fertilization; PSE, pseudostratified epithelium.