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. 2018 Aug 30;13(8):e0203409. doi: 10.1371/journal.pone.0203409

Fig 1. Tacrolimus release in blood of rats challenged or not with LPS.

Fig 1

a) Longitudinal measurements of tacrolimus in blood of rats injected subcutaneously in the hind limb with TGMS-TAC. Increased tacrolimus levels after LPS challenge in the same limb (n = 3, red line), but no increase in unchallenged animals (n = 6, black line). Upper limit of detection of tacrolimus in blood by LC-MS/MS was 65 ng/mL, higher values are not reliably measurable. b) AUC analyses of untreated and LPS-treated animals (*P < 0.05, unpaired t-test).