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. 2018 Aug 30;13(8):e0203409. doi: 10.1371/journal.pone.0203409

Fig 2. Tacrolimus levels in tissues of rats challenged or not with LPS.

Fig 2

a) Experimental set-up. TGMS-TAC treated animals received or not a subcutaneous injection of lipopolysaccharides (LPS) 7 days after TGMS-TAC injection. 48 h after LPS challenge (or no challenge for controls), tissue levels of tacrolimus were measured by LC-MS/MS in b) skin, c) muscle and d) fat pad of TGMS-TAC treated and untreated, contralateral limbs (n = 6 rats per group). b)-d) Shown are individual data points for each animal, with indication of mean ± SD by lines. Paired t-tests were used for intra-group comparisons of same tissues; unpaired t-tests were used for inter-group comparisons of same tissues from either treated or contralateral limbs (* p < 0.05, ** p < 0.01, *** p < 0.001).