. 2018 Aug 30;13(8):e0203338. doi: 10.1371/journal.pone.0203338

Table 3. Detected genes associated with resistance to different classes of antibiotics and phenotypic susceptibility profiles to most of these classes of antibiotics.

Species ID	TOB	CIP	TMP	SXT	Aminoglycoside^†	Quinolone	TMP	SUL	TET	MAC
K. pneumoniae
13	8	0.5	≥16	≥320	aac(3)-IId^a,strA,strB	oqxA^a,oqxB^a, QnrS1	dfrA1	sul1, sul2	tet(A), tet(D)
5	8	≥4	≥16	≥320	aadA16^a,aac(6')Ib-cr	oqxA^a,oqxB^a, QnrB49^a,QnrS1	dfrA27	sul1	tet(A)^a	mph(A)
19	8	1	≤0.5	≤20	aac(3)-IId^a,strA,strB	oqxA^a,oqxB^a, QnrS1		sul2	tet(D)
16	8	0.5	≥16	≤20	aac(3)-IId^a	oqxA^a,oqxB^a, QnrS1	dfrA1	sul1	tet(A)
6	8	≥4	≥16	≥320	aac(3)-IId^a,aadA16^a, strA^a,strB^a, aac(6')Ib-cr	oqxA^a,oqxB^a, QnrB6	dfrA27	sul1, sul2	tet(D)
20,21	8	≥4	≥16	≥320	aac(3)-IId^a,aadA16^a, aph(3')-Ia^a,strA,strB, aac(6')Ib-cr	oqxA^a,oqxB^a, QnrB49^a,QnrS1	dfrA27	sul2	tet(A)^a	mph(A)
18	8	0.5	8	40	aac(3)-IId^a,aadA16^a, strA^a,strB^a,aacA4^a, aac(6')Ib-cr^a	oqxA^a,oqxB^a, QnrB6	dfrA27	sul1, sul2	tet(D)
14	2	≥4	≥16	≥320	aadA16^a,aac(6')Ib-cr	oqxA,oqxB	dfrA27	sul1	tet(D)
15	4	≥4	≥16	≥320	aadA16^a,aac(6')Ib-cr	oqxA,oqxB	dfrA27	sul1	tet(D)
17	8	0.5	≥16	≥320	aac(3)-IId^a, strA^a,strB^a	oqxA^a,oqxB^a, QnrS1	dfrA14^a	sul2	tet(A)^a	mph(A)
7,8,9	8	≥4	≥16	≥320	aac(3)-IId^a,aadA16^a, aac(6')Ib-cr	oqxA^a,oqxB^a	dfrA27	sul1, sul2	tet(A)^a, tet(D)
11	8	≤0.25	≤0.5	≤20	aac(3)-IId^a, strA^a,strB^a	oqxA^a,oqxB^a, QnrB6		sul1, sul2	tet(D)
12	≤1	1	≥16	≥320	strA,strB	oqxA^a,oqxB^a, QnrS1	dfrA14^a	sul2
10	8	≥4	≥16	≥320	aac(3)-IId^a,aadA16^a, aac(6')Ib-cr	oqxA^a,oqxB^a, QnrB49^a	dfrA27	sul1, sul2	tet(A)^a, tet(D)
4	8	2	≥16	≥320	aac(3)-IId^a,aadA16^a, aph(3')-Ia^a,strA,strB, aac(6')Ib-cr	oqxA^a,oqxB^a, QnrB49^a,QnrS1	dfrA27	sul1, sul2	tet(A)^a	mph(A)
1,2,3	8	2	≥16	≥320	aac(3)-IId^a,aadA16^a, aph(3')-Ia^a,strA,strB, aac(6')Ib-cr	oqxA^a,oqxB^a, QnrB49^a,QnrS1	dfrA27	sul1, sul2	tet(A)^a	mph(A)
K. oxytoca
29	≤1	≤0.25	≤0.5	≤20	aph(3')-Ia^a
33	8	0.5	≥16	≥320	strA^a,strB^a,aacA4, aac(6')Ib-cr^a	QnrS1	dfrA14^a	sul2
32	8	≥4	≥16	≥320	aac(3)-IId^a,aadA16^a, aac(6')Ib-cr	QnrB52	dfrA27	sul1	tet(A)^a
K. variicola
34	≤1	≤0.25	≤0.5	≤20		oqxA^a,oqxB^a
E. cloacae
31	8	0.5	≥16	≥320	aac(3)-IIa^a, aadA1^a,strA,strB, aac(6')Ib-cr	QnrB1^a	dfrA14^a	sul2	tet(A)^a

^aGenes called with a less than 100% identity and or length less than 100%. Minimum identity and length for call: 90.00% and 60% respectively.

^†aac(6')Ib-cr confers resistance to aminoglycosides and quinolones.

Shading within table indicates susceptibility interpretation according to EUCAST breakpoint table version 7.1, dark grey: resistant, light grey: intermediate and white: susceptible. ID isolate identification number, TOB tobramycin, CIP ciproflacin, TMP trimethoprim, SXT trimethoprim-sulfamethoxazole, SUL sulphonamide, TET tetracyclin, MAC macrolide.