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. 2018 Aug 20;14(8):e1007153. doi: 10.1371/journal.ppat.1007153

Fig 1. Expression of CD630_16170-CD630_16190 is induced by LL-37 in a dose-dependent manner.

Fig 1

Active cultures of A) 630Δerm and B) R20291 were grown in BHIS or BHIS with 0.05, 0.1, 0.2, 0.4, 0.8 or 1.6 μg/ml LL-37. Samples were harvested, cDNA generated, and qRT-PCR performed as described in Methods. mRNA levels are normalized to expression levels in BHIS alone. Bars represent the mean and standard deviation for at least three biological replicates. Expression levels of each gene were analyzed by one-way ANOVA and Dunnett’s multiple comparisons test, comparing to expression without LL-37. Adjusted p values indicated by * ≤ 0.05, ** ≤ 0.01, *** ≤ 0.001.