Figure 7. Cartoon representation of G_qPCR-mediated reciprocal effects on capillary ion channel activity.

Schematic diagram summarizing the proposed mechanism. Top: In the absence of G_qPCR stimulation, endogenous PIP₂ levels are sufficient to tonically inhibit TRPV4 channels and maintain Kir2.1 channel activity. Bottom: G_qPCR activation with an agonist stimulates PIP₂ hydrolysis, resulting in the loss of PIP₂-mediated maintenance of Kir2.1 activity and inhibition of TRPV4 activity.