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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Trends Mol Med. 2018 Jul 11;24(9):805–820. doi: 10.1016/j.molmed.2018.06.009

Figure 5.

Figure 5

ABC transporters as molecular targets of organoids derived from intestinal stem cells and hPSCs. (A) Cellular structure of adult intestinal cells, (B) an anatomical structure of cultured intestinal cell organoids and ABC transporter expression on the plasma membrane of the lumen; (C) 2D- and 3D- presentation of CFTR (ABCC7, a cystic fibrosis-associated chloride channel protein). The locations of CFTR mutations of interest, which are associated with cystic fibrosis, are indicated by asterisks.

Abbreviations: C, the carboxyl-terminus; N, the amino-terminus; NBD, nucleotide binding domain; PDB 5UAR: Protein Data Bank, dephosphorylated, ATP-free cystic fibrosis transmembrane conductance regulator (CFTR) from zebrafish; PM, plasma membrane; TM, transmembrane segment; TMD, transmembrane domain.