Table 5.
Univariable Cox proportional hazards regression analyses of donor-specific HLA antibody (DSA) as predictors of outcome (acute cellular rejection [ACR] grade ≥ A1, ACR ≥ A2, or lymphocytic bronchiolitis [LB] grade ≥ B1R).
| DSA definition | ACR grade ≥ A1 | ACR grade ≥ A2 | LB grade ≥ B1R | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| HALT-defined DSA* | 1.42 | 0.85 – 2.38 | 0.178 | 1.42 | 0.75 – 2.69 | 0.279 | 1.18 | 0.42 – 3.34 | 0.757 |
| DSA MFI ≥ 2000* | 1.74 | 0.99 – 3.04 | 0.052 | 1.54 | 0.76 – 3.12 | 0.230 | 0.95 | 0.27 – 3.29 | 0.929 |
| DSA MFI ≥ 3000* | 1.80 | 0.98 – 3.28 | 0.057 | 2.11 | 1.04 – 4.27 | 0.039 | 1.19 | 0.34 – 4.12 | 0.788 |
| Number of DSA** specificities | 1.22 | 0.96 – 1.54 | 0.105 | 1.32 | 1.02 – 1.72 | 0.038 | 1.19 | 0.78 – 1.80 | 0.423 |
| DSA Class** | 0.668 | 0.159 | 0.964 | ||||||
| No DSA (reference) | 1.00 | 1.00 | 1.00 | ||||||
| Class I only | 0.84 | 0.33 – 2.11 | 0.705 | 1.01 | 0.31 – 3.31 | 0.993 | 0.82 | 0.11 – 6.33 | 0.851 |
| Class II only | 1.06 | 0.59 – 1.91 | 0.842 | 0.94 | 0.43 – 2.06 | 0.869 | 1.18 | 0.38 – 3.67 | 0.772 |
| Class I and Class II | 1.66 | 0.70 – 3.92 | 0.252 | 2.71 | 1.11 – 6.60 | 0.029 | 0.70 | 0.09 – 5.39 | 0.732 |
ACR: acute cellular rejection
LB: lymphocytic bronchiolitis
MFI: mean fluorescence intensity
*
Analyzed as a time-dependent variable
**
DSA defined according to HALT study criteria (i.e., HALT-defined DSA)