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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Toxicol Pathol. 2018 Jul 25;46(6):706–718. doi: 10.1177/0192623318789398

Figure 3.

Figure 3

Analysis of mutational spectra of spontaneous tumors and tumors from mice treated with GBE or MEG. (A) The spectra of mutations based on the trinucleotide content (one nucleotide before to one nucleotide after the mutation). (B) Hierarchical clustering based on the Kullback-Leibler distance method after accounting for the differences in the trinucleotide composition of the human and mouse genomes. The six sets of samples were classified together with 30 “signatures” from COSMIC database