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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Toxicol Pathol. 2018 Jul 25;46(6):706–718. doi: 10.1177/0192623318789398

Table 1.

Variants of Ctnnb1 and Hras identified by Sanger sequencing and exome sequencing*

Gene mutation Tumors from mice that were used for exome sequencing Tumors from other mice
Spontaneous GBE MEG Spontaneous GBE MEG
Sanger
(n=3)
Exome-Seq, FF
(n=3)
Exome-Seq, PE
(n=3)
Sanger
(n=4)
Exome-Seq, FF
(n=4)
Exome-Seq, PE
(n=4)
Sanger
(n=3)
Exome-Seq, FF
(n=3)
Exome-Seq, PE
(n=3)
Sanger
(n=10)
Sanger
(n=10)
Sanger
(n=7)
Ctnnb1 Q28L 1
D32N 1 1 1
D32H 1
D32Y 1 1
G34R 1
T41A 1 1
T41L 2
T42P 1
S45F 1
Δ5-13 1
Δ5-26 1
Hras Q61L 1 1 1
Q61K 2 2 2 6 2
Q61R 1 1 1 1 1
*

Abbreviations: GBE, ginkgo biloba extract; MEG, methyleugenol; FF, exome sequencing for fresh frozen tissue; PE, exome sequencing for formalin-fixed paraffin-embedded tissue