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. Author manuscript; available in PMC: 2019 Aug 1.

Published in final edited form as: Toxicol Pathol. 2018 Jul 25;46(6):706–718. doi: 10.1177/0192623318789398

Table 2.

Variants from exome sequencing that correspond to known mutations in human cancer-related genes from publicly available databases^*

Gene	mutation	Spontaneous						GBE								MEG						Database match			SIFT score
		1		2		3		1		2		3		4		1		2		3		Database match			SIFT score
		FF	PE	FF	PE	FF	PE	FF	PE	FF	PE	FF	PE	FF	PE	FF	PE	FF	PE	FF	PE	COSMIC	IntOGen	NIEHS
Acss3	G672V																	X	X			yes			0.08
Bcl11a	A189T																			X	X	yes			0.06
Braf	V637E																			X	X	yes	yes	yes	0
Clta	N88S					X	X											X	X			yes			0.28
Ctnnb1	D32N																	X				yes	yes	yes	0
	D32Y																			X		yes			0
	T41A													X								yes			0
Dnahc5	E3279K															X	X					yes			0.38
Elmo1	G125A																				X	yes			0
Elk3	P88L																				X	yes			0.06
Gnas	R926C																	X	X				yes		0
Hras	Q61K	X	X	X	X																	yes	yes	yes	0.1
Hras	Q61R															X	X					yes		yes	0
Kif3c	E76K																				X	yes			0.09
Lrp1b	R1646K																			X	X	yes			0.85
Lyst	Y2952C																			X		yes			0
Rbbp5	L399V																				X	yes			0.08
Slc2a13	R601W																		X			yes			0.01

^*

Abbreviations: GBE, ginkgo biloba extract; MEG, methyleugenol; FF, fresh frozen tissue; PE, formalin-fixed paraffin-embedded tissue