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. 2018 Aug 24;5:77. doi: 10.3389/fmolb.2018.00077

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Copyright © 2018 Di Mise, Ranieri, Centrone, Venneri, Tamma, Valenti and Valenti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NPS-R568 treatment results in a complete recovery of cell energy status in human ciPTEC-PC1KD. The ATP level in human ciPTEC was measured in three independent experiments for each experimental group and expressed as nmol ATP/mg protein. (A) CaSR stimulation elicited by NPS-R568 induced a significant increase in cellular ATP content in ciPTEC-PC1KD, restoring levels comparable to ciPTECwt at basal conditions. Data were analyzed by One-way ANOVA followed by Newman–Keuls multiple comparisons test and are expressed as means ± SEM (****P < 0.0001 vs. ciPTECwt Basal or ciPTEC-PKD1+NPS-R568). (B) IP3R inhibition with 2-APB in ciPTEC-PC1KD prevented cellular ATP levels rescue induced by CaSR activation. Data were analyzed by Two-way ANOVA followed by Turkey's multiple comparisons test and are expressed as means ± SEM (****P < 0.0001 vs. NPS-R568 treatment in each cell line).