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. 2018 Aug 30;8:13103. doi: 10.1038/s41598-018-31288-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of spleens from B16F1 tumour-bearing WT and Ats1-KO mice. (a) Graph representing spleen index (as indicated in Methods section) of healthy and tumour-bearing mice (WT, n = 6; Ats1-KO, n = 5) to assess splenomegaly. (b) Graph representing flow cytometry data, as percentage of positive cells of the following populations: CD45R⁺, CD3⁺, CD11b⁺, CD11b⁺/GR1⁺, and F4/80⁺, found in spleens of healthy WT (n = 6) and tumour-bearing WT (n = 5), and healthy Ats1-KO (n = 5) and tumour-bearing Ats1-KO (n = 5) mice. Blue-dashed bars represent comparison between WT and Ats1-KO groups. (c) Graph representing the mRNA fold change expression of Adamts1, Cd3g, Cd4, Il6, Il10, and Il12a in spleens of healthy WT (n = 5) and tumour-bearing WT (n = 5) and healthy Ats1-KO (n = 5) and tumour-bearing Ats1-KO (n = 6) mice. All values are relative to healthy WT. For all the graphs, results are shown as the median with s.e.m. and statistical significance (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001).