Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 30;9(9):895. doi: 10.1038/s41419-018-0924-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a, b Percentage of cells showing >3 53BP1 nuclear bodies (a) and DNA damage as measured by the neutral comet assay (b), performed in LAN5 (MNA) and SK-N-SH (MNSC) cell lines treated with mirin or vehicle, for 5 h. For all panels, average data obtained by three independent experiments are reported as fold induction compared to untreated controls, ±SD). p-Values were calculated by the ANOVA test. **p < 0.01. Representative images of LAN5 cells treated with DMSO (above) or mirin (below) are given in the insets. c Evaluation of cell death and DDR in MNA (LAN5, IMR32, Kelly) and MNSC (GIMEN, SK-N-SH) cell lines, as measured by the trypan blue exclusion test (upper panel; average data obtained by three independent experiments are reported as fold induction compared to untreated controls, ±SD), and by WB analysis of the indicated proteins and phosphoepitopes (bottom panel), following mirin treatment. p-Values were calculated by the Student’s t-test. ***p < 0.001. d Percentage of TUNEL-positive apoptotic cells in LAN5 and SK-N-SH cell lines, following mirin treatment, for the indicated time points. Data obtained by three independent experiments are reported as percentage compared to untreated controls, ±SD. p-Values were calculated by the Student’s t-test. **p < 0.01