Figure 5.
Recovery of the HB-19 complexed with nucleolin from lymphoid organs. Rats were intravenously injected with 1 mg of either the biotin-labeled HB-19 or its corresponding control peptide, the biotin-labeled CP-51. At 45 min postinjection, tissue extracts were prepared as described in Materials and Methods. The HB-19 (A) or CP-51 (B) bound proteins were assayed by dot-immunoblotting using the antinucleolin polyclonal antibody. The HB-19 bound proteins were also analyzed by immunoblotting after SDS/PAGE, using mAb D3 (C). A single band was identified by the antinucleolin antibody. C shows a section of the immunoblot (10% gel) at the region of the nucleolin migration (95 kDa).