Table 3.

Univariate and multivariate analysis of OS in patients with oral cavity squamous cell carcinoma after treatment.

Variables	Univariate			Multivariate
	Hazards Ratio	95% CI	P-value	Hazards Ratio	95% CI	P-value
Age (Years)
≤65	Reference			Reference
>65	1.435	1.011–2.039	0.0434†	1.528	1.063–2.197	0.0220†
Sex
Male	Reference			Reference
Female	1.226	0.779–1.928	0.3781	1.158	0.725–1.850	0.5381
Overall Pathological Stage
I	Reference			Reference
II	2.345	1.110–4.954	0.0256†	2.603	1.181–5.738	0.0177†
III	3.679	1.735–7.798	0.0007†	3.391	1.504–7.644	0.0032†
IV	7.690	3.912–15.117	<0.0001†	4.928	2.213–10.974	<0.0001†
ENE
(−)	Reference			Reference
(+)	3.665	2.725–4.929	<0.0001†	2.096	1.477–2.975	<0.0001†
Perineural Invasion
No	Reference			Reference
Yes	1.926	1.453–2.553	<0.0001†	1.061	0.764–1.473	0.7222
Cell Differentiation*
W-D + M-D	Reference			Reference
P-D	1.916	1.305–2.814	0.0009†	1.359	0.908–2.034	0.1363
Tumor Depth (mm)
<10 mm	Reference			Reference
≥10 mm	2.423	1.801–3.259	<0.0001†	1.119	0.773–1.619	0.5517
Surgical margin
<5 mm	Reference			Reference
≥5 mm	0.696	0.518–0.934	0.0158†	0.914	0.675–1.238	0.5622
Albumin (gl−1)
≥4.5	Reference
<4.5	2.109	1.575–2.825	<0.0001†
NLR
≤2.28	Reference
>2.28	1.759	1.320–2.345	0.0001†
ANS
score = 0	Reference			Reference
score = 1	1.802	1.201–2.703	0.0044†	1.550	1.020–2.354	0.0400†
score = 2	3.181	2.124–4.763	<0.0001†	1.962	1.283–3.001	0.0019†

Abbreviations: OS = overall survival; CI = confidence interval; ENE = extranodal extension; NLR = neutrophil-t-lymphocyte ratio; ANS = albumin/NLR score.

*W-D = well-differentiated, M-D = moderately differentiated, and P-D = poorly differentiated, squamous cell carcinoma.

^†Statistically significant.