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. 2018 Aug 30;8:13066. doi: 10.1038/s41598-018-31397-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of H5N1 polymerase mutations on mortality and weight loss of infected mice. Five-week-old BALB/c mice were inoculated intranasally with serial 10-fold dilutions of the indicated VN/HN viruses. (A) Body weight of mice (5 mice per group) infected with the indicated viruses was monitored for 14 d post-infection. The mean ± SD of the percent body weight change for each group of infected mice is shown. The numbers on the curves show the numbers of surviving animals. (B) Survival of mice (5 mice per group) infected with 10 FFU of the indicated viruses. Mortality was calculated including mice that were sacrificed after they had lost more than 30% of their body weight. (C) Effect of H5N1 polymerase mutations on virus yields in infected mice lungs. Virus titers in the lungs of five-week-old BALB/c mice (5 mice per group) infected with 100 FFU of the indicated VN/HN viruses were measured at 3 d (left) and 6 d (right) post-infection. Each symbol marks the titer in an individual mouse. An asterisk indicates a P value < 0.01 (ANOVA with Tukey’s multiple comparison test).