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. 2018 Aug 30;8:13064. doi: 10.1038/s41598-018-30875-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Validation of the chronic restraint stress (RS) animal model. (A) Cumulative time in open, closed, and center areas in the elevated plus maze (EPM), and heat map of animals’ movements on the EPM. (B) The level of plasma corticosterone (CORT) one day after the last stress exposure. (C) Body weight changes over the 3-week period. (D) Blood pressure one day after the last stress exposure. CTR, control group; RS, restraint stress group; *p < 0.05; **p < 0.01; ***p < 0.001.