Table 3.
Significant annotations among 117 types of adipose related tissue- and cell-specific functional annotations with frequencies, effect size estimates, and related p-values from likelihood ratio tests
| Annotation class | Frequency | Estimate of annotation effect (ϒk) | Prior probability | Log2 relative causal probability | LRT p-value |
|---|---|---|---|---|---|
| Adipose Nuclei-H2AK9ac (imputed)a | 1.11% | −1.95 | 4.48 × 10−2 | 2.76 | 7.85 × 10−4 |
| Adipocyte-H2BK20ac (imputed)a | 1.56% | −1.79 | 3.84 × 10−2 | 2.53 | 3.99 × 10−3 |
| Adipocyte-EnhG (core 15-state model)a | 1.44% | −1.51 | 2.98 × 10−2 | 2.15 | 1.29 × 10−2 |
| Adipocyte-H2AK5ac (imputed)a | 3.88% | −0.95 | 1.71 × 10−2 | 1.36 | 3.37 × 10−2 |
| Adipocyte-DNase (imputed)a | 8.18% | −0.58 | 1.17 × 10−2 | 0.83 | 4.09 × 10−2 |
| Adipocyte-Tx (core 15-state model) | 4.51% | 4.29 | 1.01 × 10−4 | −6.19 | 4.27 × 10−2 |
a Top five annotations used in the final PAINTOR model