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. 2018 Aug 30;8:13096. doi: 10.1038/s41598-018-31253-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of TSHR antibodies in GO mouse model. Total TSHR antibodies and stimulating activity of antibodies was measured in sera of individual male or female mice immunized either with ß-Gal (males n = 8, females n = 16) or hTSHR A-subunit plasmid (males n = 14; females n = 14). (A) Total TSHR antibodies (TRAbs) were measured by TSH binding inhibitory immunoglobulin activity to the human TSHR given as % inhibition of TSH. (B) Stimulating activity of antibodies (TSAbs) was evaluated by bioassay using CHO cells stably expressing the mouse TSHR. Stimulating activity is given in cAMP (pmol/ml). Statistical significance is indicated ****p ≤ 0.0001, ***p ≤ 0.001, **p ≤ 0.01, ns not significant.