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. 2018 Aug 30;8:13096. doi: 10.1038/s41598-018-31253-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inspection of mice eye symptoms indicating orbital disease. During the entire experimental course the mice were individually inspected for eye signs indicating orbital disease (ß-Gal males n = 10, females n = 17; hTSHR males n = 15, females n = 14). (A) Representative images of a ß-Gal mouse showing any pathological eye signs (left) and of hTSHR mice with acute symptoms of inflammation like red canthus and pus (middle) or with proptosis (right). Percentage of male or female mice showing eye symptoms is indicated. (B) Percentage of hTSHR mice showing eye symptoms during the course of immunizations (Symptomatic mice). Eye signs were monitored during the three weeks between the immunizations and after the 4th immunization before scarifying the animals. On the x axis the time points are defined as after the 1st, second, third and fourth immunization.