Skip to main content
. 2018 Aug 30;8:13096. doi: 10.1038/s41598-018-31253-4

Figure 6.

Figure 6

Comparison of male versus female GO mouse model. To compare the total outcome of male versus female autoimmune hyperthyroidism or associated orbitopathy, the characteristic parameters were normalized by the Z-Score method. (A) Z-Score of autoimmune hyperthyroidism includes values of TSAbs (Fig. 1), T4 and thyroid area (Fig. 2). (ß-Gal males n = 10, females n = 15; hTSHR males n = 14, females n = 14) (B) Z-Score of orbitopathy evaluated by MRI includes parameter inflammatory infiltration, fat extension and GaG deposition (Fig. 4). (ß-Gal males n = 4, females n = 6; hTSHR males n = 6, females n = 5) (C) Z-Score of orbitopathy characterized by the histological parameter of, abundance of macropahes, T cells, muscle fiber hypertrophy, BAT extension and collagen deposition (Fig. 5). (ß-Gal males n = 8, females n = 15; hTSHR males n = 14, females n = 14). Statistical significance is given with **p ≤ 0.01, *p ≤ 0.05, ns non-significant.