Table 1.
Classification of autoimmune hyperthyroidism and Graves’ orbitopathy in male versus female GO mouse model.
| Disease classification | Z-Score | Males | Females | ||
|---|---|---|---|---|---|
| No | % | No | % | ||
| Autoimmune hyperthyroidism | |||||
| Subclinical | ≤0 | 4 | 28.6 | 3 | 21.4 |
| Clinical | >0 | 10 | 71.4 | 11 | 78.6 |
| Mild | >0–1 | 7 | 50.0 | 4 | 28.5 |
| Moderate-to-severe | >1 | 3 | 21.4 | 5 | 35.7 |
| Graves’ orbitopathy MRI | |||||
| Subclinical | ≤0 | 2 | 33.3 | 1 | 20.0 |
| Clinical | >1 | 4 | 66.7 | 4 | 80.0 |
| Mild | >0–1 | 3 | 50.0 | 3 | 60.0 |
| Moderate-to-severe | >1 | 1 | 16.7 | 1 | 20.0 |
| Graves’ orbitopathy Histology | |||||
| Subclinical | ≤0 | 5 | 35.7 | 4 | 28.6 |
| Clinical | >0 | 9 | 64.3 | 10 | 71.4 |
| Mild | >0–1 | 8 | 57.1 | 7 | 50.0 |
| Moderate-to-severe | >1 | 1 | 14.3 | 3 | 21.4 |
Disease classification was done along the Z-score values in Fig. 6. Number of mice is given in (No) or %. Subclinical disease (Z-score < 0): Finally these mice did not significantly manifest autoimmune hyperthyroidism and/or GO although these hTSHR A-subunit immunized mice developed TSHR autoantibodies and/or transient inflammatory eye symptoms. Clinical disease (Z-score > 0): These mice significantly manifested chronical disease during the experimental course. Clinical disease is classified in mild and moderate/severe in accordance with the Z-score values as indicated (mild: Z-score > 0–1; moderate/sever: Z-score > 1).