Fig. 3. Overexpression of SNHG5 represses cell apoptosis and promotes hepatoma cell proliferation, invasion and migration in vitro.

a qRT–PCR analysis of SNHG5 expression after SNHG5 overexpression. **P < 0.01. b MTT assay showed SNHG5 overexpression promotes HCC cells proliferation. *P < 0.05. c–f FACS analysis showed overexpression of SNHG5 represses cell apoptosis, induces cell cycle progression. g Common cell cycle-related and apoptosis-related proteins expression levels detected by western blot analysis following SNHG5 upregulation. h–j Transwell and wound healing assays after SNHG5 overexpression. *P < 0.05; **P < 0.01. k Expression levels of MMP-2 and MMP-9 in HCC cells after SNHG5 overexpression were analyzed by western blot