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. 2018 Aug 30;9(9):888. doi: 10.1038/s41419-018-0882-5

Fig. 4. Knockdown of SNHG5 represses tumor growth and metastasis in vivo.

Fig. 4

a Representative images of nude mice modles and formed tumors that were subcutaneously injected with SNHG5-shRNA and NC-shRNA cells. b, c Effect of SNHG5 knockdown on HCC growth in vivo according to the tumor growth curve and tumor weight. *P < 0.05; **P < 0.01. d, e Representative images of HE and IHC staining patterns for Ki-67 in tumor xenografts of nude mice (200×). **P < 0.01. f, g Representative images of pulmonary metastatic models and HE staining of metastatic nodules in the lungs. (200× and 400×), **P < 0.01. h The expression of SNHG5, miR-26a-5p, and GSK3β in xenograft tumors were detected by qRT-PCR. **P < 0.01. i, j Pearson’s correlation analysis of the relationship between SNHG5 and miR-26a-5p, SNHG5, and GSK3β expression levels in xenograft tumors