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. 2018 Aug 30;9:3522. doi: 10.1038/s41467-018-05624-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Associations with LDL cholesterol (LDL-C). a Scatter plot summarizing pheWAS analyses for a genetic predictor of LDL-C. Blue and green colored circles denote associations that are significant at Bonferroni p < 0.05 and FDR q < 0.1, respectively. b Association analysis between the LDL genetic predictor and the PheWAS septicemia phenotype, stratified by type 2 diabetes (T2D) status. Error bars represent 95% confidence intervals of odds-ratio estimates. c Epidemiological association between the Low (LDL-C < 60 mg/dl) versus Normal LDL-C (between 90 and 130 mg/dl) and septicemia, stratified by T2D status, using an independent EHR cohort. Odds-ratios were determined by multivariable logistic regression adjusting for age, gender and race and stratified by T2D status. Error bars represent 95% confidence intervals. T2D type 2 diabetes