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. 2018 Aug 24;9:1906. doi: 10.3389/fimmu.2018.01906

Figure 9.

Figure 9

Expression of CCL17, arachidonate 15-lipoxygenase, type B (ALOX15B), and sterol regulatory element binding protein (SREBP)-2 target genes in asthmatic subjects. (A) CCL17 and ALOX15B expression in bronchial alveolar lavage (BAL) cells isolated from healthy controls (n = 12), moderate asthmatics (n = 28), and severe asthmatics (n = 41). P-values were calculated using one-way ANOVA with Bonferroni post hoc means comparisons with significance level set at 0.05. *P < 0.05, ***P < 0.001. (B) Expression of SREBP-2 target gene lanosterol synthase (LSS), low density lipoprotein receptor (LDLR), 7-dehydrocholesterol reductase (DHCR7), SREBP cleavage-activating protein (SCAP), 24-dehydrocholesterol reductase (DHCR24), SREBP2, insulin-induced gene 1 (INSIG1), phosphomevalonate kinase (PMVK), acetoacetyl-CoA synthetase (AACS), mevalonate kinase (MVK), 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) in BAL cells isolated from control subjects and severe asthmatics. P-values were calculated using two-tailed Student’s t-test. *P < 0.05. (C) Pairwise correlations of gene expression in BAL cells isolated from severe asthmatics. The heat map indicates pairwise correlation strength (Spearman’s ρ) between ALOX15B and SREBP-2 target genes.